Melanotan II (10 mg Vial) Dosage Protocol

Quickstart Highlights

Melanotan II is a synthetic analog of α-melanocyte-stimulating hormone studied for its ability to increase skin pigmentation and noted for inducing erectile activity as a side effect^[1]. Early human trials identified effective daily doses in the range of 1–2 mg for tanning, with conservative protocols starting lower to minimize side effects such as nausea and flushing^[2]^[3]. This educational protocol presents a once-daily subcutaneous titration approach using practical dilution for clear insulin-syringe measurements.

Reconstitute: Add 3.0 mL bacteriostatic water → 3.33 mg/mL concentration.

Typical daily range: 250–1000 mcg once daily (gradual titration over 8–12 weeks).

Easy measuring: At 3.33 mg/mL, 1 unit = 0.01 mL ≈ 33.3 mcg on a U-100 insulin syringe.

Storage: Lyophilized: freeze at −20 °C (−4 °F) or below; after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); use within 1–2 weeks.

Dosing & Reconstitution Guide

Educational guide for reconstitution and daily dosing

Standard / Gradual Titration (3 mL = 3.33 mg/mL)

Week / Phase	Daily Dose	Units (per injection) (mL)
Week 1	250 mcg (0.25 mg)	7.5 units (0.075 mL)
Week 2	500 mcg (0.5 mg)	15 units (0.15 mL)
Week 3	750 mcg (0.75 mg)	22.5 units (0.225 mL)
Weeks 4–8	1000 mcg (1 mg)	30 units (0.30 mL)
Maintenance (after Week 8)	500–1000 mcg (1–2× weekly)	15–30 units (0.15–0.30 mL)

Frequency: Inject once daily subcutaneously during the initial 8-week tanning phase; transition to 1–2 injections per week for maintenance dosing to sustain pigmentation^[3]. This schedule uses the standard 3.0 mL dilution for consistent unit measurements. For ≤10-unit (≤0.10 mL) administrations, consider 30- or 50-unit insulin syringes for improved readability.

Reconstitution Steps

Draw 3.0 mL bacteriostatic water with a sterile syringe.

Inject slowly down the vial wall to avoid foaming; do not shake vigorously.

Gently roll or swirl the vial until the powder is fully dissolved.

Label the vial with the reconstitution date and store refrigerated at 2–8 °C (35.6–46.4 °F), protected from light.

Important: This guide is for educational purposes only and is not medical advice. Melanotan II is not an approved medication. For research use only.

Supplies Needed

Plan based on an 8–16 week daily protocol with gradual titration (including transition to maintenance dosing).

Peptide Vials (Melanotan II, 10 mg each):

8 weeks ≈ 5 vials (~45–50 mg total)
12 weeks ≈ 8 vials (~70–75 mg total)
16 weeks ≈ 10 vials (~95–100 mg total)

Insulin Syringes (U-100, 1 mL):

Per week (daily dosing): 7 syringes
8 weeks: 56 syringes
12 weeks: 84 syringes
16 weeks: 112 syringes

Bacteriostatic Water (10 mL bottles): Use 3.0 mL per vial for reconstitution.

8 weeks (5 vials): 15 mL → 2 × 10 mL bottles
12 weeks (8 vials): 24 mL → 3 × 10 mL bottles
16 weeks (10 vials): 30 mL → 3 × 10 mL bottles

Alcohol Swabs: One for the vial stopper + one for the injection site each day.

Per week: 14 swabs (2/day)
8 weeks: 112 swabs → recommend 2 × 100-count boxes
12 weeks: 168 swabs → recommend 2 × 100-count boxes
16 weeks: 224 swabs → recommend 3 × 100-count boxes

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Protocol Overview

Concise summary of the once-daily subcutaneous regimen.

Goal: Increase skin pigmentation (tanning) through melanocortin receptor activation^[1].

Schedule: Daily subcutaneous injections for 6–8 weeks during loading phase, then maintenance dosing 1–2× weekly^[3].

Dose Range: 250–1000 mcg daily with gradual titration to minimize side effects.

Reconstitution: 3.0 mL per 10 mg vial (3.33 mg/mL) for accurate unit measurements.

Storage: Lyophilized frozen at −20 °C (−4 °F); reconstituted refrigerated at 2–8 °C (35.6–46.4 °F); use within 1–2 weeks^[7].

Research Disclaimer