Sermorelin (10 mg Vial) Dosage Protocol

Quickstart Highlights

Sermorelin is a synthetic growth hormone–releasing hormone (GHRH) analog that stimulates endogenous pituitary GH secretion^[1]. Originally approved for pediatric growth hormone deficiency, it is studied for adult off‑label use to support physiologic GH output and IGF‑1 levels^[2]. This educational protocol presents a once‑daily subcutaneous approach administered at bedtime to align with natural nocturnal GH release^[3].

Reconstitute: Add 3.0 mL bacteriostatic water → ~3.33 mg/mL concentration.

Typical daily range: 200–500 µg once daily at bedtime (gradual titration).

Easy measuring: At 3.33 mg/mL, 1 unit = 0.01 mL ≈ 33.3 µg on a U‑100 insulin syringe.

Storage: Lyophilized: refrigerate at 2–8 °C (36–46 °F); after reconstitution, refrigerate at 2–8 °C (36–46 °F) and use within 10–14 days^[4].

Dosing & Reconstitution Guide

Educational guide for reconstitution and nightly dosing

Standard / Gradual Approach (3 mL = ~3.33 mg/mL)

Week	Daily Dose (µg)	Units (per injection) (mL)
Weeks 1–2	200 µg (0.2 mg)	6 units (0.06 mL)
Weeks 3–4	300 µg (0.3 mg)	9 units (0.09 mL)
Weeks 5–6	400 µg (0.4 mg)	12 units (0.12 mL)
Weeks 7–8	500 µg (0.5 mg)	15 units (0.15 mL)

Frequency: Inject once daily subcutaneously at bedtime. Bedtime administration is strongly recommended because endogenous GH secretion peaks during sleep^[3]. This schedule uses the largest practical dilution (3.0 mL) to keep per‑injection units measurable with standard insulin syringes.

For ≤10‑unit (≤0.10 mL) administrations, consider 30‑ or 50‑unit insulin syringes for improved readability.

Reconstitution Steps

Draw 3.0 mL bacteriostatic water with a sterile syringe.

Inject slowly down the vial wall; gently swirl to dissolve (do not shake vigorously)^[2].

Label with reconstitution date and refrigerate at 2–8 °C (36–46 °F), protected from light^[2]^[4].

Wipe vial stopper with alcohol before each use; use a new sterile needle and syringe for each injection^[2].

Important: This guide is for educational purposes only and is not medical advice. For research use only. Not for human consumption.

Supplies Needed

Plan based on an 8–week daily protocol with gradual titration (56 injections total).

Peptide Vials (Sermorelin, 10 mg each):

8 weeks (total ~19.6 mg consumed): 2 vials (20 mg total)
12 weeks (similar daily range): 4 vials
Tip: Have 1 extra vial as backup in case of spillage or loss.

Insulin Syringes (U‑100):

Per week: 7 syringes (1/day)
8 weeks: 56 syringes (recommend 1 × 100‑count box)
12 weeks: 84 syringes (1 × 100‑count box)
Preferred: 0.3–0.5 mL size with 28G–31G needle, 5/16″ to 1/2″ length for subcutaneous use. Consider 30‑ or 50‑unit syringes for low‑dose weeks for improved precision.

Bacteriostatic Water (10 mL bottles): Use ~3.0 mL per vial for reconstitution.

8 weeks (2 vials): 6 mL → 1 × 10 mL bottle
12 weeks (4 vials): 12 mL → 2 × 10 mL bottles
Contains benzyl alcohol preservative; do not use if allergic.

Alcohol Swabs: One for the vial stopper + one for the injection site each day.

Per week: 14 swabs (2/day)
8 weeks: 112 swabs → recommend 2 × 100‑count boxes
12 weeks: 168 swabs → recommend 2 × 100‑count boxes

Sharps Container: One puncture‑proof disposal container for used needles (sufficient for 56+ syringes).

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Protocol Overview

Concise summary of the once‑daily nightly regimen.

Goal: Stimulate endogenous pituitary GH release to support physiologic IGF‑1 levels and anabolic processes^[1]^[2].

Schedule: Daily subcutaneous injections at bedtime for 3–6 months (pediatric trials ran 6–12 months; adult use is off‑label)^[1].

Dose Range: 200–500 µg daily (adult research range; pediatric: 30 µg/kg nightly)^[1]^[2].

Reconstitution: 3.0 mL per 10 mg vial (~3.33 mg/mL) for accurate unit measurements.

Storage: Lyophilized refrigerated; reconstituted refrigerated and used within 10–14 days^[4].

Research Disclaimer