Tesamorelin (10 mg Vial) Dosage Protocol

Quickstart Highlights

Tesamorelin is a synthetic 44-amino-acid peptide analog of Growth Hormone-Releasing Hormone (GHRH)^[1]. It stimulates endogenous growth hormone release and raises IGF-1 levels, leading to enhanced lipolysis and metabolic benefits^[2]. Tesamorelin is FDA-approved for reducing visceral adipose tissue in HIV-associated lipodystrophy and is studied for metabolic disorders and aging research^[3]^[4].

Reconstitute: Add 3.0 mL bacteriostatic water per 10 mg vial → ~3.33 mg/mL concentration.

Standard daily dose: 2 mg (2000 mcg) once daily subcutaneously (FDA-approved protocol).

Easy measuring: At 3.33 mg/mL, 1 unit = 0.01 mL ≈ 33.3 mcg on a U-100 insulin syringe.

Storage: Lyophilized & Reconstituted: refrigerate at 2–8 °C (35.6–46.4 °F)

Dosing & Reconstitution Guide

Educational guide for reconstitution and daily dosing

Standard FDA-Approved Protocol (3.0 mL = ~3.33 mg/mL)

Week	Daily Dose (mg / mcg)	Units (per injection) (mL)
Week 1	1 mg / 1000 mcg	30 units (0.30 mL)
Weeks 2–12+	2 mg / 2000 mcg	60 units (0.60 mL)

Frequency: Inject once daily subcutaneously, preferably in the evening to coincide with nocturnal GH release^[5]^[6]. The 2 mg daily dose is the standard FDA-approved regimen for HIV lipodystrophy^[7]^[8]. A one-week titration at 1 mg may improve tolerability before advancing to the full 2 mg dose.

Reconstitution Steps

Draw 3.0 mL bacteriostatic water with a sterile syringe.

Inject slowly down the vial wall; avoid foaming.

Gently swirl until dissolved (do not shake).

Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.

Important: This guide is for educational purposes only and is not medical advice.

Supplies Needed

Plan based on an 8–16 week daily protocol at the standard 2 mg dose (after Week 1 titration).

Peptide Vials (Tesamorelin, 10 mg each):

8 weeks ≈ 11 vials (105 mg total)
12 weeks ≈ 17 vials (161 mg total)
16 weeks ≈ 22 vials (217 mg total)

Insulin Syringes (U-100, 1 mL capacity):

Per week: 7 syringes (1/day)
8 weeks: 56 syringes
12 weeks: 84 syringes
16 weeks: 112 syringes

Bacteriostatic Water (10 mL bottles): Use 3.0 mL per vial for reconstitution.

8 weeks (11 vials): 33 mL → 4 × 10 mL bottles
12 weeks (17 vials): 51 mL → 6 × 10 mL bottles
16 weeks (22 vials): 66 mL → 7 × 10 mL bottles

Alcohol Swabs: One for the vial stopper + one for the injection site each day.

Per week: 14 swabs (2/day)
8 weeks: 112 swabs → recommend 2 × 100-count boxes
12 weeks: 168 swabs → recommend 2 × 100-count boxes
16 weeks: 224 swabs → recommend 3 × 100-count boxes

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Protocol Overview

Concise summary of the FDA-approved once-daily regimen.

Goal: Reduce visceral adipose tissue and improve lipid profiles through sustained GH/IGF-1 elevation^[3]^[4].

Schedule: Daily subcutaneous injections for 12–26 weeks (extendable to 52 weeks with medical supervision)^[3].

Dose: 2 mg (2000 mcg) daily after Week 1 titration.

Reconstitution: 3.0 mL per 10 mg vial (~3.33 mg/mL) for accurate measurement.

Storage: Lyophilized refrigerated; reconstituted refrigerated; avoid freeze-thaw.

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