HMG (0.15 mg / 75 IU Vial) Dosage Protocol

Quickstart Highlights

Human Menopausal Gonadotropin (HMG) is a purified gonadotropin preparation containing equal amounts of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity^[1]^[2]. In males, HMG is used alongside hCG to stimulate spermatogenesis in cases of hypogonadotropic hypogonadism or infertility^[3]^[4]. This educational protocol presents a thrice-weekly subcutaneous approach for male fertility support.

Reconstitute: Add 3.0 mL bacteriostatic water → 25 IU/mL concentration.

Typical protocol: 75 IU three times weekly for 12–16 weeks, usually combined with hCG therapy.

Volume consideration: Each 75 IU dose = 3.0 mL, requiring a 3 mL syringe or multiple 1 mL injections.

Storage: Lyophilized: refrigerate at 2–8 °C (35.6–46.4 °F); after reconstitution, use promptly or refrigerate and use within a few days.

Dosing & Reconstitution Guide

Educational guide for reconstitution and thrice-weekly dosing

Male Fertility Protocol (3 mL = 25 IU/mL)

Week/Phase	Dose per Injection	Volume per Injection
Weeks 1–12	75 IU (0.15 mg)	3.0 mL (300 units)
Weeks 13–16 (optional extension)	75 IU (0.15 mg)	3.0 mL (300 units)

Frequency: Inject three times per week subcutaneously (for example, Monday, Wednesday, and Friday)^[3]^[4]. HMG therapy is typically combined with hCG injections to maximize testosterone production and spermatogenesis^[5]^[6].

Important Volume Note: Each full 75 IU dose requires 3.0 mL, which exceeds standard 1 mL insulin syringe capacity. Options include:

Use a 3 mL syringe (preferred for single injection)

Split dose into three 1 mL injections at different sites (1 mL = 25 IU each)

Consider smaller reconstitution volume (1 mL) per manufacturer guidance for reduced injection volume^[8]

Reconstitution Steps

Draw 3.0 mL bacteriostatic water with a sterile 3 mL syringe.

Inject slowly down the vial wall to avoid foaming.

Gently swirl or roll the vial until fully dissolved (do not shake).

Label with date and time; refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.

For optimal potency, use reconstituted solution promptly or within a few days^[9].

Important: This guide is for therapeutic educational purposes only and does not constitute medical advice, diagnosis, or treatment. For research use only.

Supplies Needed

Plan based on a 12–16 week male fertility protocol with thrice-weekly administration.

Peptide Vials (HMG, 75 IU / 0.15 mg each):

12 weeks ≈ 36 vials (3 per week × 12 weeks)
16 weeks ≈ 48 vials (3 per week × 16 weeks)

Syringes (3 mL):

Per week: 3 syringes (one per injection)
12 weeks: 36 syringes
16 weeks: 48 syringes

Note: If using 1 mL insulin syringes, multiply counts by 3 for split-dose administration.

Bacteriostatic Water (30 mL bottles): Use 3.0 mL per vial for reconstitution.

12 weeks (36 vials): 108 mL → 4 × 30 mL bottles
16 weeks (48 vials): 144 mL → 5 × 30 mL bottles

Alcohol Swabs: One for the vial stopper + one for each injection site.

Per week: 6 swabs (2 per injection day)
12 weeks: 72 swabs → recommend 1 × 100-count box
16 weeks: 96 swabs → recommend 1 × 100-count box

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Protocol Overview

Concise summary of the thrice-weekly male fertility regimen.

Goal: Stimulate spermatogenesis in males with hypogonadotropic hypogonadism or infertility^[3]^[4].

Schedule: Subcutaneous injections three times weekly for minimum 12 weeks (extend to 16 weeks if needed)^[7].

Dose: 75 IU (0.15 mg) per injection, typically combined with hCG therapy^[5]^[6].

Reconstitution: 3.0 mL per 75 IU vial (25 IU/mL) for calculation convenience.

Storage: Lyophilized refrigerated; reconstituted solution used promptly or within days when refrigerated.

Research Disclaimer