Tesamorelin 5mg + Ipamorelin 5mg (10mg Blend) Dosage Protocol

Quickstart Highlights

This blend combines tesamorelin, a synthetic GHRH analog, with ipamorelin, a selective ghrelin mimetic (growth hormone secretagogue). When administered together, GHRH analogs and ghrelin mimetics produce synergistic GH pulses^[1]^[2]. The FDA‑approved tesamorelin dose is 2 mg SC daily^[3], while ipamorelin is commonly studied at 100–300 mcg SC daily^[4]. This educational protocol presents a once‑daily subcutaneous approach with gradual titration using a 1:1 blend ratio.

Reconstitute: Add 3.0 mL bacteriostatic water to the 10 mg vial → ~3.33 mg/mL total (1.67 mg/mL each peptide).

Typical daily range: 250–2000 mcg tesamorelin + 125–1000 mcg ipamorelin (gradual titration).

Easy measuring: At 3.33 mg/mL total, 1 unit = 0.01 mL ≈ 16.7 mcg of each peptide on a U‑100 insulin syringe.

Storage: Lyophilized: refrigerate at 2–8 °C (35.6–46.4 °F); after reconstitution, use immediately or refrigerate and use within 24–48 hours^[5].

Dosing & Reconstitution Guide

Educational guide for reconstitution and daily dosing

Standard / Gradual Approach (3 mL = ~3.33 mg/mL total)

Route: Subcutaneous (SC) | Frequency: Once daily

Week	Tesamorelin Dose	Ipamorelin Dose	Units (mL)
Weeks 1–2	250 mcg (0.25 mg)	125 mcg (0.125 mg)	23 units (0.23 mL)
Weeks 3–4	500 mcg (0.5 mg)	250 mcg (0.25 mg)	45 units (0.45 mL)
Weeks 5–6	1000 mcg (1.0 mg)	500 mcg (0.5 mg)	90 units (0.90 mL)
Weeks 7–10	1500 mcg (1.5 mg)	750 mcg (0.75 mg)	135 units (1.35 mL)
Weeks 11–16	2000 mcg (2.0 mg)	1000 mcg (1.0 mg)	180 units (1.80 mL)

Note: The 1:1 blend ratio means tesamorelin and ipamorelin are present in equal amounts per mL. At 3.0 mL reconstitution: 1 mL = 1.67 mg tesamorelin + 1.67 mg ipamorelin. Higher‑volume injections (≥1.0 mL) may be split across two sites if preferred for comfort.

Reconstitution Steps

Draw 3.0 mL bacteriostatic water with a sterile syringe.

Inject slowly down the vial wall; avoid foaming.

Gently swirl/roll until dissolved (do not shake).

Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light; use within 24–48 hours^[5].

Important: This guide is for educational purposes only and is not medical advice. For research use only. Not for human consumption.

Supplies Needed

Plan based on an 8–16 week daily protocol with gradual titration.

Peptide Vials (Tesamorelin 5 mg + Ipamorelin 5 mg, 10 mg blend each):

8 weeks ≈ 10 vials
12 weeks ≈ 19 vials
16 weeks ≈ 31 vials

Insulin Syringes (U‑100):

Per week: 7 syringes (1/day)
8 weeks: 56 syringes
12 weeks: 84 syringes
16 weeks: 112 syringes

Bacteriostatic Water (10 mL bottles): Use ~3.0 mL per vial for reconstitution.

8 weeks (10 vials): 30 mL → 3 × 10 mL bottles
12 weeks (19 vials): 57 mL → 6 × 10 mL bottles
16 weeks (31 vials): 93 mL → 10 × 10 mL bottles

Alcohol Swabs: One for the vial stopper + one for the injection site each day.

Per week: 14 swabs (2/day)
8 weeks: 112 swabs → recommend 2 × 100‑count boxes
12 weeks: 168 swabs → recommend 2 × 100‑count boxes
16 weeks: 224 swabs → recommend 3 × 100‑count boxes

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Protocol Overview

Concise summary of the once‑daily regimen.

Goal: Support pulsatile GH release through dual GHRH + ghrelin pathway stimulation^[1]^[2].

Schedule: Daily subcutaneous injections for 8–16 weeks.

Dose Range: Tesamorelin 250–2000 mcg + ipamorelin 125–1000 mcg daily with gradual titration.

Reconstitution: 3.0 mL per 10 mg vial (~3.33 mg/mL total) for accurate unit measurements.

Storage: Lyophilized refrigerated 2–8 °C; reconstituted use immediately or within 24–48 hours.

Research Disclaimer